14_PO-CON1714E.PDF - 第6页
6 High-sensitivity and simultaneous analysis of Psychoactive drugs using LC-MS/MS with full-automated pretreatment system Concentration in sample (μg/mL) 70% 74% 72% 73% 70% 73% 79% 77% 73% 72% 73% 76% 74% 73% 71% 79% 64…
5
High-sensitivity and simultaneous analysis of Psychoactive drugs
using LC-MS/MS with full-automated pretreatment system
Concentration in sample
(μg/mL)
84%
86%
82%
78%
83%
92%
83%
84%
84%
1
80%
80%
91%
80%
92%
80%
84%
81%
84%
10
81%
81%
84%
77%
77%
69%
76%
75%
71%
0.1
Serum
77%
79%
84%
80%
74%
73%
79%
75%
79%
1
76%
78%
79%
76%
81%
77%
77%
77%
79%
10
67%
78%
73%
72%
70%
67%
72%
68%
75%
0.1
Whole blood
103%
103%
102%
109%
101%
107%
97%
110%
104%
1
89%
92%
89%
92%
86%
88%
84%
95%
92%
10
90%
88%
87%
95%
92%
78%
76%
81%
91%
0.1
Urine
Allobarbital (neg)
Amobarbital (neg)
Barbital (neg)
Pentobarbital (neg)
Phenobarbital (neg)
Secobarbital (neg)
Thiamylal (neg)
Thiopental (neg)
Bromovalerylurea
Concentration in sample
(μg/mL)
69%
73%
70%
72%
68%
70%
68%
84%
73%
69%
75%
0.1
80%
80%
74%
77%
80%
81%
76%
76%
80%
80%
83%
1
74%
72%
67%
74%
70%
76%
68%
79%
71%
71%
83%
0.01
Serum
66%
66%
65%
60%
64%
67%
58%
77%
64%
104%
70%
0.1
70%
73%
83%
89%
77%
87%
67%
81%
70%
116%
83%
1
64%
66%
63%
57%
63%
64%
56%
78%
55%
89%
68%
0.01
Whole blood
84%
86%
78%
83%
86%
84%
83%
85%
83%
84%
87%
0.1
102%
101%
99%
103%
100%
100%
101%
111%
100%
103%
106%
1
87%
90%
82%
90%
88%
86%
91%
90%
91%
89%
87%
0.01
Urine
Amitriptyline
Amoxapine
Clomipramine
Desipramine
Dosulepin
Imipramine
Maprotiline
Mianserin
Nortriptyline
Promethazine
Setiptiline
6
High-sensitivity and simultaneous analysis of Psychoactive drugs
using LC-MS/MS with full-automated pretreatment system
Concentration in sample
(μg/mL)
70%
74%
72%
73%
70%
73%
79%
77%
73%
72%
73%
76%
74%
73%
71%
79%
64%
73%
73%
70%
77%
70%
73%
73%
73%
82%
78%
76%
71%
70%
72%
70%
74%
70%
72%
74%
71%
72%
71%
0.1
82%
78%
86%
81%
80%
74%
82%
77%
79%
81%
80%
79%
80%
93%
79%
73%
87%
76%
78%
79%
73%
80%
81%
77%
89%
73%
70%
82%
82%
83%
87%
76%
79%
79%
78%
78%
78%
78%
86%
1
69%
73%
72%
76%
84%
73%
90%
82%
72%
82%
77%
79%
79%
75%
75%
82%
56%
76%
75%
80%
81%
74%
75%
80%
N.A.
78%
73%
78%
73%
72%
71%
84%
70%
79%
75%
75%
74%
74%
74%
0.01
Serum
75%
76%
73%
73%
77%
76%
80%
74%
74%
73%
75%
74%
73%
73%
70%
77%
68%
70%
73%
76%
75%
72%
75%
74%
73%
78%
77%
73%
75%
76%
74%
72%
70%
70%
75%
75%
73%
75%
74%
0.1
86%
77%
85%
82%
90%
85%
89%
83%
82%
80%
95%
87%
82%
97%
81%
92%
75%
76%
79%
91%
103%
84%
85%
77%
88%
86%
81%
70%
85%
85%
95%
77%
76%
80%
79%
80%
88%
79%
95%
1
78%
82%
79%
77%
78%
81%
81%
80%
80%
76%
81%
74%
76%
73%
70%
79%
55%
86%
75%
77%
83%
79%
76%
75%
N.A.
81%
81%
71%
78%
80%
76%
81%
74%
71%
79%
81%
77%
79%
76%
0.01
Whole blood
93%
96%
93%
93%
91%
93%
77%
94%
95%
92%
95%
93%
95%
93%
97%
89%
89%
85%
89%
90%
93%
91%
98%
93%
70%
90%
88%
97%
93%
93%
97%
95%
89%
90%
91%
90%
90%
92%
98%
0.1
106%
112%
108%
111%
126%
116%
83%
109%
110%
112%
103%
115%
111%
99%
111%
106%
122%
103%
106%
123%
123%
104%
115%
107%
81%
107%
217%
126%
109%
110%
102%
110%
107%
104%
108%
104%
103%
106%
103%
1
98%
103%
98%
99%
97%
96%
N.A
96%
99%
90%
105%
95%
100%
92%
92%
96%
86%
115%
95%
96%
79%
94%
105%
97%
77%
94%
86%
98%
101%
93%
99%
96%
94%
86%
94%
93%
94%
109%
99%
0.01
Urine
Alprazolam
Bromazepam
Brotizolam
Chlordiazepoxide
Clorazepic acid
Clotiazepam
Cloxazolam
Diazepam
Estazolam
Ethyl loazepate
Etizolam
Fludiazepam
Flunitrazepam
Flurazepam
Flutazolam
Flutoprazepam
Haloxazolam
Lorazepam
Lormetazepam
Medazepam
Mexazolam
Midazolam
Nimetazepam
Nitrazepam
Oxazolam
Prazepam
Quazepam
Rilmazafone
Tosopam
Triazolam
Zolpidem
α-Hydroxyalprazolam
α-Hydroxybrotizolam
α-Hydroxyetizolam (M-VI)
7-Aminounitrazepam
7-Aminonimetazepam
7-Aminonitrazepam
α-Hydroxytriazolam
Zolpidem M-1
First Edition: June, 2017
© Shimadzu Corporation, 2017
High-sensitivity and simultaneous analysis of Psychoactive drugs
using LC-MS/MS with full-automated pretreatment system
These results shows the capability of the system for large sample set analyses with improved accuracy and precision by
eliminating human error associated with manual sample handling.
Conclusions
* Disclaimer: LCMS-8060 and CLAM-2000 are not registered as a Class I device, and it is available for Research
Use Only (RUO). Not for use in diagnostic procedures.