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Sp ec i a l So f t w ar e En ab le s Mor e E f f ic ien t T esti ng Pr epa r a ti on One System Plays T wo Roles, Significantly Impr oving the Thr oughput of the T esting Lab The Nexera FV is a multipurpose system for on…
System Configuration for Online Dissolution Testing
Two Analysis Modes Promote Faster Dissolution Testing
With the Nexera FV, the dissolution tester and the autosampler are connected online, so everything is automated from sampling
to dilution to data acquisition and analysis. As a result, there is less test-related work for the operator, and a subsequent increase
in processing throughput.
In addition, there is no manual dispensing of samples, ensuring reliable results.
Flow Vials Provide Automated Dissolution Testing
A dissolution medium from the dissolution tester flows
directly into flow vials loaded into the autosampler. A
bubble suppression design has been adopted for these
flow vials, enabling high-accuracy sampling of dissolution
media.
Depending on the dissolution tester used, 8 or 12 flow
vials can be loaded. Further, since the flow vials are
purposefully designed not to control the temperature, salt
precipitation from the dissolution medium is suppressed.
Dissolution
Tester
Analyze
Directly
Dissolution
Tester
Fractionate
Analyze
Direct Injection Analysis Mode: Exclusively with the Nexera System
In this mode, the dissolution medium delivered from the dissolution tester is directly loaded and analyzed. This is effective if the
analysis of the number of vessels finishes before the next sampling interval.
This analysis mode can be selected precisely because the Nexera FV is compatible with UHPLC analysis.
Fraction Analysis Mode: For Confirmation of Dissolution Profiles
at Short Sampling Intervals
This analysis mode is used for tests in which the sampling interval is short. This is suitable when checking the
dissolution profile of instantly soluble samples. The Nexera autosampler's high-speed performance makes this
system compatible with sampling intervals as short as five minutes. In addition, up to 768 samples can be
fractionated, making this mode effective when the dissolution quantity is large and dilution will be required.
Dissolution tester Filter station
Nexera FV
PC
Connected online
4
5
Special Software Enables More Efficient Testing Preparation
One System Plays Two Roles, Significantly Improving the
Throughput of the Testing Lab
The Nexera FV is a multipurpose system for on-line dissolution testing and high-efficiency UHPLC analysis, such as compound
screening, and everyday method development applications. This significantly increases the system operation rate in the
laboratory.
Rapid Confirmation of Test Results and Automatic Generation of Reports
DT-Solution Software Supports the Creation and Implementation
of Test Schedules
With dissolution tests, one of the most labor-intensive
processes is establishing a batch schedule for the test. The
custom DT-Solution software eases the burden. With this
software, the user can configure all the required information
in a single window. Then, click a single button to
automatically generate a batch schedule in LabSolutions
™
software so that testing can start. In dissolution tests
performed with the Nexera FV, preparation time is minimal.
The browser function built into LabSolutions is convenient for
assessing changes in the chromatogram over time. Multiple
data sets can be displayed simultaneously in a single window,
so the data can be compared at a glance. In addition, the
creation of reports can be completely automated with the
multi-data report function. When the test finishes, a result
table, pivot graphs, and test pass/fail judgments for each
component are created automatically, so the test results can
be rapidly confirmed.
Reliable Performance Expands the Range of Choices
Compatible with High-Concentration Samples Requiring Dilution
High dissolution quantity samples often require
dilution. Samples can be diluted by using the fraction
analysis mode. High injection accuracy is provided
even at trace quantities, enabling reliable dilution
even without manual handling.
The data shows a comparison between a standard
liquid (aqueous caffeine solution), with the dilution
ratios manually adjusted by an experienced engineer,
and a standard liquid automatically diluted by the
Nexera FV. This data shows that the system can
perform dilution reliably.
Long-Lasting Consumables Provide for High Cost-Effectiveness
A special septum is used for the flow vial that receives the dissolution medium. It boasts a
better degree of adherence after needle penetration in comparison to a regular septum, and
can be used for 100 continuous injections without leaking. This greatly reduces maintenance,
enabling continuous testing.
Dilution Ratio (Times)
2
5
10
100
100
101
20 101
50
100
101
102
Dilution Accuracy (%)
or
6
7
Special Software Enables More Efficient Testing Preparation
One System Plays Two Roles, Significantly Improving the
Throughput of the Testing Lab
The Nexera FV is a multipurpose system for on-line dissolution testing and high-efficiency UHPLC analysis, such as compound
screening, and everyday method development applications. This significantly increases the system operation rate in the
laboratory.
Rapid Confirmation of Test Results and Automatic Generation of Reports
DT-Solution Software Supports the Creation and Implementation
of Test Schedules
With dissolution tests, one of the most labor-intensive
processes is establishing a batch schedule for the test. The
custom DT-Solution software eases the burden. With this
software, the user can configure all the required information
in a single window. Then, click a single button to
automatically generate a batch schedule in LabSolutions
™
software so that testing can start. In dissolution tests
performed with the Nexera FV, preparation time is minimal.
The browser function built into LabSolutions is convenient for
assessing changes in the chromatogram over time. Multiple
data sets can be displayed simultaneously in a single window,
so the data can be compared at a glance. In addition, the
creation of reports can be completely automated with the
multi-data report function. When the test finishes, a result
table, pivot graphs, and test pass/fail judgments for each
component are created automatically, so the test results can
be rapidly confirmed.
Reliable Performance Expands the Range of Choices
Compatible with High-Concentration Samples Requiring Dilution
High dissolution quantity samples often require
dilution. Samples can be diluted by using the fraction
analysis mode. High injection accuracy is provided
even at trace quantities, enabling reliable dilution
even without manual handling.
The data shows a comparison between a standard
liquid (aqueous caffeine solution), with the dilution
ratios manually adjusted by an experienced engineer,
and a standard liquid automatically diluted by the
Nexera FV. This data shows that the system can
perform dilution reliably.
Long-Lasting Consumables Provide for High Cost-Effectiveness
A special septum is used for the flow vial that receives the dissolution medium. It boasts a
better degree of adherence after needle penetration in comparison to a regular septum, and
can be used for 100 continuous injections without leaking. This greatly reduces maintenance,
enabling continuous testing.
Dilution Ratio (Times)
2
5
10
100
100
101
20 101
50
100
101
102
Dilution Accuracy (%)
or
6
7