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www.shimadzu.com/an/ For Research Use Only . Not for use in diagnostic procedures. This publication may contain references to pr oducts that are not available in your country . Please contact us to check the availability…
Special Software Enables More Efficient Testing Preparation
One System Plays Two Roles, Significantly Improving the
Throughput of the Testing Lab
The Nexera FV is a multipurpose system for on-line dissolution testing and high-efficiency UHPLC analysis, such as compound
screening, and everyday method development applications. This significantly increases the system operation rate in the
laboratory.
Rapid Confirmation of Test Results and Automatic Generation of Reports
DT-Solution Software Supports the Creation and Implementation
of Test Schedules
With dissolution tests, one of the most labor-intensive
processes is establishing a batch schedule for the test. The
custom DT-Solution software eases the burden. With this
software, the user can configure all the required information
in a single window. Then, click a single button to
automatically generate a batch schedule in LabSolutions
™
software so that testing can start. In dissolution tests
performed with the Nexera FV, preparation time is minimal.
The browser function built into LabSolutions is convenient for
assessing changes in the chromatogram over time. Multiple
data sets can be displayed simultaneously in a single window,
so the data can be compared at a glance. In addition, the
creation of reports can be completely automated with the
multi-data report function. When the test finishes, a result
table, pivot graphs, and test pass/fail judgments for each
component are created automatically, so the test results can
be rapidly confirmed.
Reliable Performance Expands the Range of Choices
Compatible with High-Concentration Samples Requiring Dilution
High dissolution quantity samples often require
dilution. Samples can be diluted by using the fraction
analysis mode. High injection accuracy is provided
even at trace quantities, enabling reliable dilution
even without manual handling.
The data shows a comparison between a standard
liquid (aqueous caffeine solution), with the dilution
ratios manually adjusted by an experienced engineer,
and a standard liquid automatically diluted by the
Nexera FV. This data shows that the system can
perform dilution reliably.
Long-Lasting Consumables Provide for High Cost-Effectiveness
A special septum is used for the flow vial that receives the dissolution medium. It boasts a
better degree of adherence after needle penetration in comparison to a regular septum, and
can be used for 100 continuous injections without leaking. This greatly reduces maintenance,
enabling continuous testing.
Dilution Ratio (Times)
2
5
10
100
100
101
20 101
50
100
101
102
Dilution Accuracy (%)
or
6
7
Special Software Enables More Efficient Testing Preparation
One System Plays Two Roles, Significantly Improving the
Throughput of the Testing Lab
The Nexera FV is a multipurpose system for on-line dissolution testing and high-efficiency UHPLC analysis, such as compound
screening, and everyday method development applications. This significantly increases the system operation rate in the
laboratory.
Rapid Confirmation of Test Results and Automatic Generation of Reports
DT-Solution Software Supports the Creation and Implementation
of Test Schedules
With dissolution tests, one of the most labor-intensive
processes is establishing a batch schedule for the test. The
custom DT-Solution software eases the burden. With this
software, the user can configure all the required information
in a single window. Then, click a single button to
automatically generate a batch schedule in LabSolutions
™
software so that testing can start. In dissolution tests
performed with the Nexera FV, preparation time is minimal.
The browser function built into LabSolutions is convenient for
assessing changes in the chromatogram over time. Multiple
data sets can be displayed simultaneously in a single window,
so the data can be compared at a glance. In addition, the
creation of reports can be completely automated with the
multi-data report function. When the test finishes, a result
table, pivot graphs, and test pass/fail judgments for each
component are created automatically, so the test results can
be rapidly confirmed.
Reliable Performance Expands the Range of Choices
Compatible with High-Concentration Samples Requiring Dilution
High dissolution quantity samples often require
dilution. Samples can be diluted by using the fraction
analysis mode. High injection accuracy is provided
even at trace quantities, enabling reliable dilution
even without manual handling.
The data shows a comparison between a standard
liquid (aqueous caffeine solution), with the dilution
ratios manually adjusted by an experienced engineer,
and a standard liquid automatically diluted by the
Nexera FV. This data shows that the system can
perform dilution reliably.
Long-Lasting Consumables Provide for High Cost-Effectiveness
A special septum is used for the flow vial that receives the dissolution medium. It boasts a
better degree of adherence after needle penetration in comparison to a regular septum, and
can be used for 100 continuous injections without leaking. This greatly reduces maintenance,
enabling continuous testing.
Dilution Ratio (Times)
2
5
10
100
100
101
20 101
50
100
101
102
Dilution Accuracy (%)
or
6
7
www.shimadzu.com/an/
For Research Use Only. Not for use in diagnostic procedures.
This publication may contain references to products that are not available in your country. Please contact us to check the availability of
these products in your country.
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its subsidiaries or its affiliates, whether or not they are used with trademark symbol “TM” or “®”.
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© Shimadzu Corporation, 2021
First Edition: September 2017 3655-08004-PDFIT
Ultra High Performance Liquid Chromatograph for Online Dissolution Testing
Nexera FV
C190-E214B
Nexera FV
Nexera and LabSolutions are trademarks of Shimadzu Corporation.